The relationship between pathological brain activity and functional network connectivity in glioma patients.

ABSTRACT:

Purpose

Glioma is associated with pathologically high (peri)tumoral brain activity, which relates to faster progression. Functional connectivity is disturbed locally and throughout the entire brain, associating with symptomatology. We, therefore, investigated how local activity and network measures relate to better understand how the intricate relationship between the tumor and the rest of the brain may impact disease and symptom progression.

Methods

We obtained magnetoencephalography in 84 de novo glioma patients and 61 matched healthy controls. The offset of the power spectrum, a proxy of neuronal activity, was calculated for 210 cortical regions. We calculated patients' regional deviations in delta, theta and lower alpha network connectivity as compared to controls, using

SUBMITTER: Zimmermann MLM 

PROVIDER: S-EPMC10876827 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature