Up-regulation of MIC19 promotes growth and metastasis of hepatocellular carcinoma by activating ROS/NF-κB signaling.

ABSTRACT:

Background

Mitochondrial malfunction has been well-recognized as a critical step in the pathogenesis of many types of diseases, including cancer. MIC19 is a core a subunit of the MICOS complex that plays a critical role in maintaining the normal function of mitochondria. However, the biological functions of MIC19 in human hepatocellular carcinoma (HCC) remain unclear.

Methods

The expression level of MIC19 in HCC was evaluated by bioinformatics analysis, quantitative real-time PCR and immunohistochemistry staining assays. Cell growth and metastasis experiments were used to assess the biological functions of MIC19 in HCC cells.

Findings

MIC19 expression was frequently upregulated in both human HCC specimens and cell lines, and its upregulation is closely associated with

SUBMITTER: Meng Z 

PROVIDER: S-EPMC10876907 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature