The clinical implication and translational research of OSCC differentiation.

ABSTRACT:

Background

The clinical value and molecular characteristics of tumor differentiation in oral squamous cell carcinoma (OSCC) remain unclear. There is a lack of a related molecular classification prediction system based on pathological images for precision medicine.

Methods

Integration of epidemiology, genomics, experiments, and deep learning to clarify the clinical value and molecular characteristics, and develop a novel OSCC molecular classification prediction system.

Results

Large-scale epidemiology data (n = 118,817) demonstrated OSCC differentiation was a significant prognosis indicator (p < 0.001), and well-differentiated OSCC was more chemo-resistant than poorly differentiated OSCC. These results were confirmed in the TCGA database and in vitro. Furthermore, we f

SUBMITTER: Shang Q 

PROVIDER: S-EPMC10876927 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature