Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells.

ABSTRACT: In the central nervous system, oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, allowing for ongoing myelination and myelin repair. With age, differentiation efficacy decreases and myelin repair fails; therefore, recent therapeutic efforts have focused on enhancing differentiation. Many cues are thought to regulate OPC differentiation, including neuronal activity, which OPCs can sense and respond to via their voltage-gated ion channels and glutamate receptors. However, OPCs' density of voltage-gated ion channels and glutamate receptors differs with age and brain region, and correlates with their proliferation and differentiation potential, suggesting that OPCs exist in different functional cell states, and that age-asso

SUBMITTER: Kamen Y 

PROVIDER: S-EPMC10876931 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature