Complexation-driven assembly of imine-linked helical receptors showing adaptive folding and temperature-dependent guest selection.

ABSTRACT: The development of synthetic receptors capable of selectively binding guests with diverse structures and multiple functional groups poses a significant challenge. Here, we present the efficient assembly of foldamer-based receptors for monosaccharides, utilising the principles of complexation-induced equilibrium shifting and adaptive folding. Diimine 4 can be quantitatively assembled from smaller components when D-galactose is added as a guest among monosaccharides we examined. During this assembly, dual complexation-induced equilibrium shifts toward both the formation of diimine 4 and the conversion of D-galactose into α-D-galactofuranose are observed. Diimine 6 is quantitatively assembled in the presence of two different guests, methyl β-D-glucopyranoside and methyl β-D-galactopyranoside,

SUBMITTER: Song G 

PROVIDER: S-EPMC10876968 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature