Effects of different KRAS mutants and Ki67 expression on diagnosis and prognosis in lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) is a prevalent form of non-small cell lung cancer with a rising incidence in recent years. Understanding the mutation characteristics of LUAD is crucial for effective treatment and prediction of this disease. Among the various mutations observed in LUAD, KRAS mutations are particularly common. Different subtypes of KRAS mutations can activate the Ras signaling pathway to varying degrees, potentially influencing the pathogenesis and prognosis of LUAD. This study aims to investigate the relationship between different KRAS mutation subtypes and the pathogenesis and prognosis of LUAD. A total of 63 clinical samples of LUAD were collected for this study. The samples were analyzed using targeted gene sequencing panels to obtain sequencing data. To complement the datase

SUBMITTER: Wang J 

PROVIDER: S-EPMC10876986 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature