Evaluation of nucleotide MALDI-TOF-MS for the identification of Mycobacterium species.

ABSTRACT:

Background

The accurate identification of the Mycobacterium tuberculosis complex (MTBC) and different nontuberculous mycobacteria (NTM) species is crucial for the timely diagnosis of NTM infections and for reducing poor prognoses. Nucleotide matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been extensively used for microbial identification with high accuracy and throughput. However, its efficacy for Mycobacterium species identification has been less studied. The objective of this study was to evaluate the performance of nucleotide MALDI-TOF-MS for Mycobacterium species identification.

Methods

A total of 933 clinical Mycobacterium isolates were preliminarily identified as NTM by the MPB64 test. These i

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10876993 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature