Middle aged CAMKII-Cre:Cbs^fl/fl mice: a new model for studying perioperative neurocognitive disorders.

ABSTRACT: Postoperative complications, such as perioperative neurocognitive disorders (PND), have become a major issue affecting surgical outcomes. However, the mechanism of PND remains unclear, and stable animal models of middle-aged PND are lacking. S-adenosylmethionine (SAM), a cystathionine beta-synthase (CBS) allosteric activator, can reduce the level of plasma homocysteine and prevent the occurrence of PND. However, the time and resource-intensive process of constructing models of PND in elderly animals have limited progress in PND research and innovative therapy development. The present study aimed to construct a stable PND model in middle-aged CAMKII-Cre:Cbs^fl/fl mice whose Cbs was specifically knocked out in CAMKII positive neurons. Behavioral tests showed that these middle-aged

SUBMITTER: Li Z 

PROVIDER: S-EPMC10877146 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature