Development and implementation of a prognostic model for clear cell renal cell carcinoma based on heterogeneous TLR4 expression.

ABSTRACT:

Objective

Clear cell renal cell carcinoma (ccRCC) is the most common subtype among renal cell carcinomas and has the worst prognosis, originating from renal tubular epithelial cells. Toll-like receptor 4 (TLR4) plays a crucial role in ccRCC proliferation, infiltration, and metastasis. The aim of this study was to construct a prognostic scoring model for ccRCC based on TLR4 expression heterogeneity and to explore its association with immune infiltration, thereby providing insights for the treatment and prognostic evaluation of ccRCC.

Methods

Using R software, a differential analysis was conducted on normal samples and ccRCC samples, and in conjunction with the KEGG database, a correlation analysis for the clear cell renal cell carcinoma pathway (hsa05211) was carried out. We

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC10877190 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature