Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells.

ABSTRACT: Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)-positive regulatory T cells (T_reg cells). Maternal microchimeric cells and accumulation of T_reg cells with noninherited maternal antigen (NIMA) specificity are similarly overturned in daughters after pregnancy, highlighting a fixed microchimeric cell niche. Whereas NIMA-specific tolerance is functionally erased by pregnancy, partner-specific resiliency against pregnancy complications persists in mothers desp

SUBMITTER: Shao TY 

PROVIDER: S-EPMC10877202 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature