The gut microbiota regulates the depressive-type behaviors and inflammatory processes after severe burn injuries in mice.

ABSTRACT: An emerging number of studies have recently revealed the correlation between burn injuries and psychological disorders. Gut microbiota and inflammatory factors may play a vital role in this process. Nevertheless, there are few studies conducted to disclose the potential mechanism of the gut microbiota between depression and burn injuries. In this study, we constructed a burn model of C57BL/6 mice, which showed that the symptom of depression became more and more severe with the burn of mice lasted longer. Meanwhile, there are significant differences of composition of gut microbiota among mice before and after burn. Then, we tested the inflammatory factors in the brain and peripheral blood, which showed an increased expression of Iba1, VWF, TNF-α and IL-6, and a decreased expression of IL-10

SUBMITTER: Chen L 

PROVIDER: S-EPMC10877245 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature