Langmuir monolayer studies of non-ionic surfactants and DOTMA for the design of ophthalmic niosomes.

ABSTRACT: The worldwide increase in diabetes entails a rise in associated diseases, with diabetic retinopathy on the forefront of the ocular complications. To overcome the challenges posed by ocular barriers, self-assembled nanocarriers have gathered increasing attention in recent years, with niosomes revealing themselves to be suitable for the delivery of a variety of drugs. This study investigated the mechanical properties of Langmuir monolayers comprising cholesterol, Tween 60, and 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), both individually and in binary and ternary systems. The cholesterol monolayer was characterized by an L-shaped isotherm, reflecting two surface aggregation states. Tween 60 exhibited expanded conformation and progressive aggregation, transitioning throug

SUBMITTER: Kattar A 

PROVIDER: S-EPMC10877279 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature