Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches.

ABSTRACT: In the development of novel antidiabetic agents, a novel series of isoxazolidine-isatin hybrids were designed, synthesized, and evaluated as dual α-amylase and α-glucosidase inhibitors. The precise structures of the synthesized scaffolds were characterized using different spectroscopic techniques and elemental analysis. The obtained results were compared to those of the reference drug, acarbose (IC₅₀ = 296.6 ± 0.825 μM for α-amylase & IC₅₀ = 780.4 ± 0.346 μM for α-glucosidase). Among the title compounds, 5d exhibited impressive α-amylase and α-glucosidase inhibitory activity with IC₅₀ values of 30.39 ± 1.52 μM and 65.1 ± 3.11 μM, respectively, followed by 5h (IC₅₀ = 46.65 ± 2.3 μM; IC₅₀ = 85.16 ± 4.25 μM) and 5f (I

SUBMITTER: Ghannay S 

PROVIDER: S-EPMC10877290 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature