Hemodynamic impact of increasing time between fentanyl and propofol administration during anesthesia induction: a randomised, clinical trial.

ABSTRACT:

Background and objective

Anesthesia induction can produce severe propofol dose-dependent hypotension. Fentanyl coadministration reduces the catecholaminergic response to orotracheal intubation allowing propofol dose reduction. The aim of this study is to determine whether the hemodynamic response is improved by increasing the time between fentanyl and propofol administration and reducing the dose of the latter without increasing the time to achieve optimal hypnosis.

Methods

After approval by the Research Ethics Committee, patients undergoing non-cardiac surgery with endotracheal intubation were randomized by a computer-generated table into six time-dose groups (1 or 2...minutes/1, 1.5, or 2...mg.kg^-1 of propofol). Patients with high bronchoaspiration risk, a diffi

SUBMITTER: Vullo PA 

PROVIDER: S-EPMC10877358 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature