Tenascin-C as a potential biomarker and therapeutic target for esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

To establish a prognostic model of esophageal squamous cell carcinoma (ESCC) patients based on tenascin-C (TNC) expression level and clinicopathological characteristics, and to explore the therapeutic potential of TNC inhibition.

Methods

The expression of TNC was detected using immunohistochemistry (IHC) in 326 ESCC specimens and 50 normal esophageal tissues. Prognostic factors were determined by Cox regression analyses and were incorporated to establish the nomogram. The effects of TNC knockdown on ESCC cells were assessed in vitro and in vivo. Transcriptome sequencing (RNA-seq) and gene set enrichment analysis (GSEA) were performed to reveal signaling pathways regulated by TNC knockdown. The therapeutic significance of TNC knockdown combined with small-molecule inh

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10877408 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature