Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function.

ABSTRACT:

Importance

Despite decades of neuroimaging studies reporting brain structural and functional alterations in depression, discrepancies in findings across studies and limited convergence across meta-analyses have raised questions about the consistency and robustness of the observed brain phenotypes.

Objective

To investigate the associations between 6 operational criteria of lifetime exposure to depression and functional and structural neuroimaging measures.

Design, setting, and participants

This cross-sectional study analyzed data from a UK Biobank cohort of individuals aged 45 to 80 years who were enrolled between January 1, 2014, and December 31, 2018. Participants included individuals with a lifetime exposure to depression and matched healthy controls without indicat

SUBMITTER: Wang X 

PROVIDER: S-EPMC10877455 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature