Gene Expression Profiling in Pediatric Appendicitis.

ABSTRACT:

Importance

Appendicitis is the most common indication for urgent surgery in the pediatric population, presenting across a range of severity and with variable complications. Differentiating simple appendicitis (SA) and perforated appendicitis (PA) on presentation may help direct further diagnostic workup and appropriate therapy selection, including antibiotic choice and timing of surgery.

Objective

To provide a mechanistic understanding of the differences in disease severity of appendicitis with the objective of developing improved diagnostics and treatments, specifically for the pediatric population.

Design, setting, and participants

The Gene Expression Profiling of Pediatric Appendicitis (GEPPA) study was a single-center prospective exploratory diagnostic study with

SUBMITTER: Dhillon BK 

PROVIDER: S-EPMC10877506 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature