Active surveillance of carbapenemase-producing Enterobacterales using genomic sequencing for hospital-based infection control interventions.

ABSTRACT:

Background

Whole-genome sequencing (WGS) is increasingly used to characterize hospital outbreaks of carbapenemase-producing Enterobacterales (CPE). However, access to WGS is variable and testing is often centralized, leading to delays in reporting of results.

Objective

We describe the utility of a local sequencing service to promptly respond to facility needs over an 8-year period.

Methods

The study was conducted at Royal Prince Alfred Hospital in Sydney, Australia. All CPE isolated from patient (screening and clinical) and environmental samples from 2015 onward underwent prospective WGS. Results were notified to the infection control unit in real time. When outbreaks were identified, WGS reports were also provided to senior clinicians and the hospital executive admin

SUBMITTER: Lee AS 

PROVIDER: S-EPMC10877539 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature