Cerebral Microbleed Patterns and Cortical Amyloid-β: The ARIC-PET Study.

ABSTRACT:

Background

Cerebral microbleeds (CMBs) are associated with cognitive decline, but their importance outside of cerebral amyloid angiopathy and the mechanisms of their impact on cognition are poorly understood. We evaluated the cross-sectional association between CMB patterns and cerebral Aβ (amyloid-β) deposition, by florbetapir positron emission tomography.

Methods

The longitudinal ARIC study (Atherosclerosis Risk in Communities) recruited individuals from 4 US communities from 1987 to 1989. From 2012 to 2014, the ARIC-PET (Atherosclerosis Risk in Communities - Positron Emission Tomography) ancillary recruited 322 nondemented ARIC participants who completed 3T brain magnetic resonance imaging with T2*GRE as part of ARIC visit 5 to undergo florbetapir positron emission tomogr

SUBMITTER: Okine DN 

PROVIDER: S-EPMC10877560 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature