Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein.

ABSTRACT: Enabling control over the bioactivity of proteins with light, along with the principles of photopharmacology, has the potential to generate safe and targeted medical treatments. Installing light sensitivity in a protein can be achieved through its covalent modification with a molecular photoswitch. The general challenge in this approach is the need for the use of low energy visible light for the regulation of bioactivity. In this study, we report visible light control over the cytolytic activity of a protein. A water-soluble visible-light-operated tetra-ortho-fluoro-azobenzene photoswitch was synthesized by utilizing the nucleophilic aromatic substitution reaction for installing a solubilizing sulfonate group onto the electron-poor photoswitch structure. The azobenzene was attached

SUBMITTER: Volaric J 

PROVIDER: S-EPMC10877574 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature