Expanded Access to Fluoroformamidines via a Modular Synthetic Pathway.

ABSTRACT: Fluoroformamidines are an underutilized and understudied functional group despite combining two of the most highly prized elements in drug design: nitrogen and fluorine. We report a practical and modular synthesis of fluoroformamidines via the rearrangement of in situ-generated amidoximes. High yields in just 60 s at room temperature highlight the efficiency of this protocol. Furthermore, fluoroformamidines proved to be useful intermediates in the synthesis of diverse ureas and carbamimidates.

SUBMITTER: Vogel JA 

PROVIDER: S-EPMC10877594 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature