Addition of Carboxylic Acids to gem-Difluoroalkenes for the Synthesis of gem-Difluoromethylenated Compounds.

ABSTRACT: We herein describe a straightforward protocol for the synthesis of carboxylic esters containing a gem-difluoromethylene unit. Readily available carboxylic acids can act as nucleophiles to add regioselectively to tetrasubstituted or trisubstituted β,β-difluoroacrylates (formal hydroacetoxylation) for the construction of RCO₂-CF₂ bonds. Thermal conditions are sufficient without the use of catalysts or additives.

SUBMITTER: Zong Y 

PROVIDER: S-EPMC10877607 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature