Fat-to-blood recirculation of partially dysfunctional PD-1⁺CD4 Tconv cells is associated with dysglycemia in human obesity.

ABSTRACT: Obesity is characterized by the accumulation of T cells in insulin-sensitive tissues, including the visceral adipose tissue (VAT), that can interfere with the insulin signaling pathway eventually leading to insulin resistance (IR) and type 2 diabetes. Here, we found that PD-1⁺CD4 conventional T (Tconv) cells, endowed with a transcriptomic and functional profile of partially dysfunctional cells, are diminished in VAT of obese patients with dysglycemia (OB-Dys), without a concomitant increase in apoptosis. These cells showed enhanced capacity to recirculate into the bloodstream and had a non-restricted TCRβ repertoire divergent from that of normoglycemic obese and lean individuals. PD-1⁺CD4 Tconv were reduced in the circulation of OB-Dys, exhibited an altered migration

SUBMITTER: Giovenzana A 

PROVIDER: S-EPMC10877684 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature