Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site.

ABSTRACT:

Background

Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the recipient's immune system. Therefore, a detailed understanding of the innate or adaptive immune cells-derived responses against allogeneic transplanted hepatic cells is the key to rationalize cell-based therapies.

Methods

Here, we induced an acute inflammatory regenerative niche (3-96 h) on the surface of the liver by the application of cryo-injury (CI) to systematically evaluate the innate immune response against transplanted allogeneic hepatic progenitors in a sustained micro-inflammatory environment.

Results

The resulting data highlighted that the in

SUBMITTER: Abbas N 

PROVIDER: S-EPMC10877762 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature