Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds.

ABSTRACT:

Background

Domesticated pigs serve as an ideal animal model for biomedical research and also provide the majority of meat for human consumption in China. Porcine intramuscular fat content associates with human health and diseases and is essential in pork quality. The molecular mechanisms controlling lipid metabolism and intramuscular fat accretion across tissues in pigs, and how these changes in response to pig breeds, remain largely unknown.

Results

We surveyed the tissue-resident cell types of the porcine jejunum, colon, liver, and longissimus dorsi muscle between Lantang and Landrace breeds by single-cell RNA sequencing. Combining lipidomics and metagenomics approaches, we also characterized gene signatures and determined key discriminating markers of lipid digestibility,

SUBMITTER: Sun J 

PROVIDER: S-EPMC10877772 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature