Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder.

ABSTRACT:

Background

Bipolar disorder (BD) is a complex mental illness characterized by different mood states, including depression, mania/hypomania, and euthymia. This study aimed to comprehensively evaluate dynamic changes in intrinsic brain activity by using dynamic fractional amplitude of low-frequency fluctuations (dfALFF) and dynamic degree centrality (dDC) in patients with BD euthymia or depression and healthy individuals.

Methods

The resting-state functional magnetic resonance imaging data were analyzed from 37 euthymic and 28 depressed patients with BD, as well as 85 healthy individuals. Using the sliding-window method, the dfALFF and dDC were calculated for each participant. These values were compared between the 3 groups using one-way analysis of variance (ANOVA). Additiona

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10877821 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature