Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.

ABSTRACT: Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomical, and physiological characteristics. Through a focus on the excitatory V3 interneuron class, here we demonstrate that interneuron subtype diversity is delineated through a combination of neurogenesis timing and final laminar settling position. We have revealed that early-born and late-born embryonic V3 temporal classes further diversify into subclasses with spatially and molecularly discrete identities. While neurogenesis timing accounts for V3 morphological diversification, laminar settling position accounts for electrophysiological profiles distinguish

SUBMITTER: Deska-Gauthier D 

PROVIDER: S-EPMC10877927 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature