Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion.

ABSTRACT: Due to the shortage of kidneys donated for transplantation, surgeons are forced to use the organs with an elevated risk of poor function or even failure. Although the existing methods for pre-transplant quality evaluation have been validated over decades in population cohort studies across the world, new methods are needed as long as delayed graft function or failure in a kidney transplant occurs. In this study, we explored the potential of utilizing photoacoustic (PA) imaging during normothermic machine perfusion (NMP) as a means of evaluating kidney quality. We closely monitored twenty-two porcine kidneys using 3D PA imaging during a two-hour NMP session. Based on biochemical analyses of perfusate and produced urine, the kidneys were categorized into 'non-functional' and 'functional' gro

SUBMITTER: Nikolaev AV 

PROVIDER: S-EPMC10877941 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature