Reduced neural connectivity in the caudate anterior head predicts hallucination severity in schizophrenia.

ABSTRACT:

Background

Caudate functional abnormalities have been identified as one critical neural substrate underlying sensory gating impairments that lead to auditory phantom hallucinations in both patients with schizophrenia (SZ) and tinnitus, characterized by the perception of internally generated sounds in the absence of external environmental auditory stimuli. In this study, we tested the hypothesis as to whether functional connectivity abnormalities in distinct caudate subdivisions implicated in sensory gating and auditory phantom percepts in tinnitus, which are currently being localized for neuromodulation targeting using deep brain stimulation techniques, would be associated with auditory phantom hallucination severity in SZ.

Methods

Twenty five SZ and twenty eight demographic

SUBMITTER: Hinkley LBN 

PROVIDER: S-EPMC10878029 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature