Engagement of vascular early response genes typifies mild cognitive impairment.

ABSTRACT:

Introduction

Molecular responses in the brains of persons with mild cognitive impairment (MCI), the earliest transitional state between normal aging and early Alzheimer's disease (AD), are poorly understood.

Methods

We examined AD-related neuropathology and transcriptome changes in the neocortex of individuals with MCI relative to controls and temporal responses to the mild hypoxia in mouse brains.

Results

Subsets of vascular early response to hypoxia genes were upregulated in MCI prior to the buildup of AD neuropathology. Early activation of pro-angiogenic hypoxia-inducible factor signaling in response to mild hypoxia was detected in mouse brains similar to those that were altered in MCI. Protracted responses to hypoxia were characterized by activation of phosphoinos

SUBMITTER: Katsel P 

PROVIDER: S-EPMC10878080 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature