A multi-omic assessment of the mechanisms of intestinal microbes used to treat diarrhea in early-weaned lambs.

ABSTRACT: Transplant of donor microbiota can significantly alter the structure of the host's intestinal microbiota and alleviate early weaning stress. Screening for alternative-resistant products by transplanting fecal bacteria from healthy lambs is a current research trend in the livestock industry. In the present study, fecal microbiota transplantation was performed in lambs with diarrhea during early weaning. The transplanted fecal microbiota greatly reduced the diarrhea and serum inflammatory factor levels caused by early weaning. Transcriptome sequencing revealed that fecal microbiota transplantation alleviated colonic inflammation and increased the expression of colonic ion transport proteins. In addition, the levels of Streptococcus, Enterococcus, and Escherichia Shigella

SUBMITTER: Guo H 

PROVIDER: S-EPMC10878098 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature