Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.

ABSTRACT: Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular Ca²⁺-calmodulin (CaM) complex signaling, and its dysfunction is significantly implicated in brain aging and neurodegenerative diseases. We found that Ng is also expressed in human aortic endothelial cells (HAECs), and depleting Ng promotes Ca²⁺-CaM complex-dependent endothelial activation and redox imbalances. Endothelial-specific Ng knockout (Cre-CDH5-Ng^f/f) mice demonstrate a significant delay in the flow-mediated dilation (FMD) response. Therefore, it is critical to characterize how endothelial Ng expression regulates reactive oxygen species (R

SUBMITTER: Jorgensen AN 

PROVIDER: S-EPMC10878108 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature