Characterization of phage evolution and phage resistance in drug-resistant <i>Stenotrophomonas maltophilia</i>.

ABSTRACT: Phage therapy has become a viable antimicrobial treatment as an alternative to antibiotic treatment, with an increase in antibiotic resistance. Phage resistance is a major limitation in the therapeutic application of phages, and the lack of understanding of the dynamic changes between bacteria and phages constrains our response strategies to phage resistance. In this study, we investigated the changing trends of mutual resistance between Stenotrophomonas maltophilia (S. maltophilia) and its lytic phage, BUCT603. Our results revealed that S. maltophilia resisted phage infection through mutations in the cell membrane proteins, while the evolved phage re-infected the resistant strain primarily through mutations in structure-related proteins. Compared with the wild-type st

SUBMITTER: Han P 

PROVIDER: S-EPMC10878236 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature