Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway.

ABSTRACT:

Background

Arteriovenous fistula (AVF) is currently the preferred vascular access for hemodialysis patients. However, the low maturation rate of AVF severely affects its use in patients. A more comprehensive understanding and study of the mechanisms of AVF maturation is urgently needed.

Methods and results

In this study, we downloaded the publicly available datasets (GSE119296 and GSE220796) from the Gene Expression Omnibus (GEO) and merged them for subsequent analysis. We screened 84 differentially expressed genes (DEGs) and performed the functional enrichment analysis. Next, we integrated the results obtained from the degree algorithm provided by the Cytohubba plug-in, Molecular complex detection (MCODE) plug-in, weighted gene correlation network analysis (WGCNA), and Leas

SUBMITTER: Hu L 

PROVIDER: S-EPMC10878333 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature