Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia.

ABSTRACT: Rationale: Lymphopenia in coronavirus disease (COVID-19) is associated with increased mortality. Objectives: To explore the association between lymphopenia, host response aberrations, and mortality in patients with lymphopenic COVID-19. Methods: We determined 43 plasma biomarkers reflective of four pathophysiological domains: endothelial cell and coagulation activation, inflammation and organ damage, cytokine release, and chemokine release. We explored if decreased concentrations of lymphocyte-derived proteins in patients with lymphopenia were associated with an increase in mortality. We sought to identify host response phenotypes in patients with lymphopenia by cluster analysis of plasma biomarkers. Measurements and Main Results: A total of 439 general ward pat

SUBMITTER: Michels EHA 

PROVIDER: S-EPMC10878379 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature