Inhibitory Immune Checkpoint Molecule Expression in Clinical Sepsis Studies: A Systematic Review.

ABSTRACT:

Objectives

Checkpoint inhibitors have been proposed for sepsis following reports of increased checkpoint molecule expression in septic patients. To determine whether clinical studies investigating checkpoint molecule expression provide strong evidence supporting trials of checkpoint inhibitors for sepsis.

Data sources

PubMed, EMBASE, Scopus, Web of Science, inception through October 2019.

Study selection

Studies comparing checkpoint molecule expression in septic patients versus healthy controls or critically ill nonseptic patients or in sepsis nonsurvivors versus survivors.

Data extraction

Two investigators extracted data and evaluated study quality.

Data synthesis

Thirty-six studies were retrieved. Across 26 studies, compared with healthy controls, sept

SUBMITTER: Busch LM 

PROVIDER: S-EPMC10878494 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature