Perifascial areolar tissue graft promotes angiogenesis and wound healing in an exposed ischemic component rabbit model.

ABSTRACT: Multiple studies have reported the use of perifascial areolar tissue (PAT) grafts to treat wounds involving exposed ischemic tissues, avascular structures, and defective membrane structures. Our objective was to assess the quantitative effects of PAT grafts and their suitability for wounds with ischemic tissue exposure and to qualitatively determine the factors through which PAT promotes wound healing and repair. We conducted histological, immunohistochemical, and mass spectrometric analyses of the PAT grafts. PAT grafts contain numerous CD34+ progenitor/stem cells, extracellular matrix, growth factors, and cytokines that promote wound healing and angiogenesis. Furthermore, we established a male rabbit model to compare the efficacy of PAT grafting with that of an occlusive dressing treatme

SUBMITTER: Miyanaga T 

PROVIDER: S-EPMC10878522 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature