Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.

ABSTRACT: The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and co-receptors such as Neuropilin (NRP) expressed on endothelial cells. These membrane-associated receptors are not solely expressed on the cell surface, they move between the surface and intracellular locations, where they can function differently. The location of the receptor alters its ability to 'see' (access and bind to) its ligands, which regulates receptor activation; location also alters receptor exposure to subcellularly localized phosphatases, which regulates its deactivation. Thus, receptors in different subcellular locations initiate different signaling, both in terms of quantity and quality. Similarly,

SUBMITTER: Sarabipour S 

PROVIDER: S-EPMC10878527 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature