Stochastic model of vesicular stomatitis virus replication reveals mutational effects on virion production.

ABSTRACT: We present the first complete stochastic model of vesicular stomatitis virus (VSV) intracellular replication. Previous models developed to capture VSV's intracellular replication have either been ODE-based or have not represented the complete replicative cycle, limiting our ability to understand the impact of the stochastic nature of early cellular infections on virion production between cells and how these dynamics change in response to mutations. Our model accurately predicts changes in mean virion production in gene-shuffled VSV variants and can capture the distribution of the number of viruses produced. This model has allowed us to enhance our understanding of intercellular variability in virion production, which appears to be influenced by the duration of the early phase of infection,

SUBMITTER: King CR 

PROVIDER: S-EPMC10878530 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature