TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation.

ABSTRACT:

Objective

The blood-brain barrier (BBB) plays a critical role in central nervous system homeostasis, and the integrity of BBB is disrupted in many neurodegenerative diseases. Matrix metalloproteinases (MMPs) degrade the tight junctions (TJs) of endothelial cells and basement membrane components essential to BBB integrity, which leads to increased BBB permeability and allows inflammatory cells and neurotoxic substances to enter the brain. Tissue inhibitors of metalloproteinases (TIMPs), endogenous inhibitors of MMPs, regulate MMP activity, thereby maintaining BBB integrity.

Methods

The disruptive impacts of MMP-3 and MMP-9 on BBB and protective effect of TIMP-1 were investigated in a simplified in vitro model of the BBB, which was generated using rat brain microvascular endot

SUBMITTER: Ahmadighadykolaei H 

PROVIDER: S-EPMC10878538 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature