Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.

ABSTRACT:

Objectives

Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant.

Design

Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722).

Setting

One hundred-fifty-three ICUs in 13 countries.

Patients

Altogether 2693 critically ill patients with AKI, of whom 994 were North American, 1143 European, and 556 from Australia and New Zealand (ANZ).

Interventions

None.

Measurements and main results

Total mean FB to a maximum of 14 days was +7199 mL in

SUBMITTER: Vaara ST 

PROVIDER: S-EPMC10878545 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature