Top-down control of flight by a non-canonical cortico-amygdala pathway.

ABSTRACT: Survival requires the selection of appropriate behaviour in response to threats, and dysregulated defensive reactions are associated with psychiatric illnesses such as post-traumatic stress and panic disorder¹. Threat-induced behaviours, including freezing and flight, are controlled by neuronal circuits in the central amygdala (CeA)²; however, the source of neuronal excitation of the CeA that contributes to high-intensity defensive responses is unknown. Here we used a combination of neuroanatomical mapping, in vivo calcium imaging, functional manipulations and electrophysiology to characterize a previously unknown projection from the dorsal peduncular (DP) prefrontal cortex to the CeA. DP-to-CeA neurons are glutamatergic and specifically target the medial CeA, the mai

SUBMITTER: Borkar CD 

PROVIDER: S-EPMC10878556 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature