Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases.

ABSTRACT:

Background

Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and hTERT genetic polymorphisms may serve as potential biomarkers for the risk of developing asbestos-related diseases and as biomarkers of progression and chemotherapy response rate in malignant mesothelioma (MM).

Subjects and methods

We conducted two retrospective studies. In the first study, a case-control study, telomere length and hTERT polymorphisms were determined in patients with MM, subjects with pleural plaques and controls without the asbestos related disease, who were occupationally exposed to asbestos. In the second study, a longitudinal observational study, telomere length was al

SUBMITTER: Mervic A 

PROVIDER: S-EPMC10878767 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature