RAD54B promotes gastric cancer cell migration and angiogenesis via the Wnt/β-catenin pathway.

ABSTRACT:

Background

Gastric cancer is an epidemic malignancy that is commonly diagnosed at the late stage. Evidence has elucidated that RAD54B exerts a crucial role in the progress of various tumors, but its specific role and mechanism in gastric cancer remain gloomy.

Materials and methods

The level of RAD54B was detected by western blot. RAD54B expression was downregulated or upregulated in both MKN45 and AGS cells by the transfection of shRAD54B or overexpression plasmid, respectively. The role of RAD54B in the growth, migration, invasion and tube formation of gastric cancer was evaluated by Edu, colony formation, transwell and tube formation assays. In addition, the molecular mechanism of RAD54B in gastric cancer was also determined by western blot. Moreover, in vivo experi

SUBMITTER: Li J 

PROVIDER: S-EPMC10878776 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature