Scaffold-free bone-like 3D structure established through osteogenic differentiation from human gingiva-derived stem cells.

ABSTRACT:

Introduction & objectives

Stem cell therapy for regenerative medicine has been sincerely investigated, but not still popular although some clinical trials show hopeful results. This therapy is suggested to be a representative candidate such as bone defect due to the accident, iatrogenic resection oncological tumor, congenital disease, and severe periodontitis in oral region. Recently, the Bio-3D printer "Regenova®" has been introduced as an innovative three-dimensional culture system, equipped scaffold-free bio-assembling techniques without any biomaterials. Therefore, we expected a mount of bone defect could be repaired by the structure established from this Bio-3D printer using osteogenic potential stem cells.

Material & methods

The gingival tissue (1x1 mm) was removed fro

SUBMITTER: Toyoda M 

PROVIDER: S-EPMC10878834 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature