Enhanced attention in rats following blast-induced traumatic brain injury.

ABSTRACT:

Purpose

To evaluate visuo-cognitive sequelae following blast-induced traumatic brain injury in a rat model.

Methods

Rats were randomly assigned to one of four groups depending on the intensity/quantity of a blast received in a blast chamber: sham (no blast), low intensity (22 psi), medium intensity (26 psi), or three medium intensity blasts (26 psi × 3). After recovery, all subjects were given visual discrimination tasks of increasing complexity, until mastery. After behavioral training, visual function was assessed via spectral-domain optical coherence tomography and pattern electroretinogram, and the extent of retinal damage was quantified via immunohistochemistry of retinal ganglion cells.

Results

None of the measures assessing visual function revealed significant

SUBMITTER: Navarro VM 

PROVIDER: S-EPMC10878867 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature