SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.

ABSTRACT:

Background

Glioma is the most frequent type of malignancy that may damage the brain with high morbidity and mortality rates and patients' prognoses are still dismal. Ferroptosis, a newly uncovered mode of programmed cell death, may be triggered to destroy glioma cells. Nevertheless, the significance of ferroptosis-related genes (FRGs) in predicting prognosis in glioma individuals is still a mystery.

Methods

The CGGA (The Chinese Glioma Atlas), GEO (Gene Expression Omnibus), and TCGA (The Cancer Genome Atlas) databases were all searched to obtain the glioma expression dataset. First, TCGA was searched to identify differentially expressed genes (DEGs). This was followed by a machine learning algorithm-based screening of the glioma's most relevant genes. Additionally, these gen

SUBMITTER: Dai Y 

PROVIDER: S-EPMC10878878 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature