Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke.

ABSTRACT:

Background

The immune microenvironment and hypoxia play crucial roles in the pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia- and immune-related biomarkers in IS.

Methods

The IS microarray dataset GSE16561 was examined to determine differentially expressed genes (DEGs) utilizing bioinformatics-based analysis. The intersection of hypoxia-related genes and DEGs was conducted to identify differentially expressed hypoxia-related genes (DEHRGs). Then, using weighted correlation network analysis (WGCNA), all of the genes in GSE16561 dataset were examined to create a co-expression network, and module-clinical trait correlations were examined for the purpose of examining the genes linked to immune cells. The immune-related DEHRGs were subm

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10878920 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature