Identification of immune-associated genes in vascular dementia by integrated bioinformatics and inflammatory infiltrates.

ABSTRACT:

Objective

Dysregulation of the immune system plays a vital role in the pathological process of vascular dementia, and this study aims to spot critical biomarkers and immune infiltrations in vascular dementia employing a bioinformatics approach.

Methods

We acquired gene expression profiles from the Gene Expression Database. The gene expression data were analyzed using the bioinformatics method to identify candidate immune-related central genes for the diagnosis of vascular dementia. and the diagnostic value of nomograms and Receiver Operating Characteristic (ROC) curves were evaluated. We also examined the role of the VaD hub genes. Using the database and potential therapeutic drugs, we predicted the miRNA and lncRNA controlling the Hub genes. Immune cell infiltration was ini

SUBMITTER: Wu F 

PROVIDER: S-EPMC10879030 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature