Single-cell transcriptome landscape of circulating CD4⁺ T cell populations in autoimmune diseases.

ABSTRACT: CD4⁺ T cells are key mediators of various autoimmune diseases; however, their role in disease progression remains unclear due to cellular heterogeneity. Here, we evaluated CD4⁺ T cell subpopulations using decomposition-based transcriptome characterization and canonical clustering strategies. This approach identified 12 independent gene programs governing whole CD4⁺ T cell heterogeneity, which can explain the ambiguity of canonical clustering. In addition, we performed a meta-analysis using public single-cell datasets of over 1.8 million peripheral CD4⁺ T cells from 953 individuals by projecting cells onto the reference and cataloging cell frequency and qualitative alterations of the populations in 20 diseases. The analyses revealed that the 12 tr

SUBMITTER: Yasumizu Y 

PROVIDER: S-EPMC10879034 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature